Arindam Chatterjee

Arindam

Chatterjee

Assistant Professor

School of Pharmacy and Health Professions

School of Pharmacy

Bunting Hall (BUN) 206

achatterjee@ndm.edu

410-532-5042

Programs I Teach

Doctor of Pharmacy

Education

Ph.D. � Medicinal Chemistry-University of Mississippi, School of Pharmacy, University, MS, US
M.S. � Medicinal Chemistry-University of Mississippi, School of Pharmacy, University, MS, US
B.S. (Honors) � Chemistry �Calcutta University, Calcutta, India
B.Tech. � Pharmaceutical Technology-Calcutta University, Calcutta, India

Biography

Research Scientist� Pfizer, Ann Arbor, MI
Research Scientist � Eli Lilly and Company, Indianapolis, IN
NIH post-doctoral fellow � Vanderbilt University, Nashville, TN (Mentor: Dr. Craig Lindsley)
Research Assistant Professor � St. Louis University, St. Louis, MO
Senior Scientist � Washington University of St. Louis, St. Louis, MO

Research Interests

Drug discovery, computational chemistry
Neurodegeneration
Oncology
Metabolic syndrome

Dr. Chatterjee current research interest focuses on drug-discovery projects related to the development of modulators on Kinase, and Nuclear Hormone receptor targets. We are developing drug molecules to target diseases like Alzheimer Disease, Cancer, Obesity, and Type 2 Diabetes. The research involves virtual screening, core medicinal chemistry, structure-activity-relationship, analytical chemistry, and computational chemistry. We utilize these techniques to screen, design, synthesize, and characterize new molecules for the targets.

Publications and Presentations

Current Selected Publications:

�A synthetic ERR agonist alleviates metabolic syndrome�, J. Pharmacol. Expt. Ther.; 388(2), 232-243. (2024). DOI:

"Computational Methods and Tools for Sustainable and Green Approaches in Drug Discovery", in Green Approaches in Medicinal Chemistry for Sustainable Drug Design, (Second Edition) Banik B.K. Ed.; Vol 2, chapter 27, 603-616, Elsevier, ISBN 978-0-443-16164-3. (2024). DOI

�International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily�Update 2023. Pharmacol. Rev.; 75 (6), 1233-1318. (2023). DOI

�Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney�, Am. J. Pathol.; 193(12), 1969-1987, (2023). DOI:

�Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915.� Eur. J. of Med. Chem., 258, 115582. DOI

�Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity�, ACS Chem. Biol.; 18(4), 756-771, (2023), DOI:

�Preparation of substituted purines and naphthyridines as REV-ERB agonists�, WO2022093552, (2022).

�Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB�, Nat. Commun.; 13, 7131 (2022), DOI:

�CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition�, Cell Rep.; 34(8), 108768, (2021), DOI:

�A two-hit model of alcoholic liver disease that exhibits rapid, severe fibrosis�, PLoS One; 16(3), e0249316, (2021), DOI:

�LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple-negative breast cancer�, Sci. Rep.; 9(1), 19530, (2019), DOI:

�Preparation of substituted isoquinolines Lxr inverse agonists for the treatment of cancer�, WO2017223514, (2017).

��, J. Immunol.; 198, 3705-3718. (2017)DOI:

�Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis�, Cancer Cell; 28, 42-56. (2015). DOI:

�Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part I: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators�, Bioorg. Med. Chem. Let.; 25 (2), 384-388. (2015). DOI:

�Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening�, Bioorg. Med. Chem.; 22 (22), 6409-6421. (2014). DOI: